Intergenerational relationships are a vital component of twenty-first century life. This course examines such relations in regards to health from a life course perspective. We begin by examining key trends in the birth cohorts of the twentieth and twenty-first century, accompanying demographic changes, and life course perspectives on health. Then we turn to intergenerational relationships and how they are shaped by family forms, social support, the rise in multigenerational living arrangements, as well as by larger societal inequalities such as race, social class, and gender. Next, we study the organization of the U.S. welfare state, its social policies as well as its impact on various generations' access to health and wealth. Finally, we develop strategies to advocate with and on behalf of disadvantaged and vulnerable families to enhance their health and wellbeing.